Description

3-Amino-3-(3,5-Bis-Trifluoromethyl-Phenyl)-Propionic Acid is a high-value, fluorinated amino acid derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring a trifluoromethyl-substituted aromatic ring, imparts significant lipophilicity and metabolic stability, making it highly sought after for the development of novel bioactive compounds. This specialty chemical is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, particularly for the synthesis of potential drug candidates targeting central nervous system disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in neuropharmacology.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to introduce fluorine atoms, which can enhance a molecule's binding affinity, membrane permeability, and metabolic stability.
• Peptidomimetic Synthesis: Serves as a non-natural amino acid building block for creating peptide analogs with improved pharmacological profiles.
• Agrochemical Development: Employed in the synthesis of advanced herbicides and pesticides where the trifluoromethyl group is a common bioisostere.
• Material Science Precursor: Potential use in the synthesis of specialty polymers and advanced materials requiring fluorinated aromatic components.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the life sciences industry.

Basic Information

Product Name	3-Amino-3-(3,5-Bis-Trifluoromethyl-Phenyl)-Propionic Acid
CAS No.	682802-95-5
Molecular Formula	C12H9F6NO2
Molecular Weight	313.20 g/mol
Synonyms	3-Amino-3-[3,5-bis(trifluoromethyl)phenyl]propanoic acid; β-Amino-β-[3,5-bis(trifluoromethyl)phenyl]propionic Acid; (3-Amino-3-(3,5-bis(trifluoromethyl)phenyl)propanoic acid; 3-Amino-3-(3,5-di(trifluoromethyl)phenyl)propionic acid; 682802-95-5; 3-(3,5-Bis(trifluoromethyl)phenyl)-3-aminopropanoic acid
EINECS	Contact for details

Quality Control

Our 3-Amino-3-(3,5-Bis-Trifluoromethyl-Phenyl)-Propionic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity assessment, to ensure it meets the exacting standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles as determined by HPLC, NMR, and other relevant techniques.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.