Description

Cyclopentanecarbonitrile, 2-(Acetyloxy)-1-Methyl-, (1R,2R)- (9Ci) is a high-purity, stereochemically defined chiral intermediate of significant value in advanced organic synthesis. Its precise (1R,2R) configuration makes it a critical building block for the development of enantiomerically pure pharmaceuticals and fine chemicals, ensuring the desired biological activity and regulatory compliance of the final product. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures. The CAS number for this specific stereoisomer is 682746-81-2.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and cardiovascular drug candidates.
• Asymmetric Synthesis: Utilized as a precursor or auxiliary in catalytic asymmetric reactions to introduce stereogenic centers with high enantiomeric excess.
• Agrochemical Research: Serves as a building block for developing novel, enantiopure herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Development: Used in the preparation of chiral ligands for transition metal catalysis or organocatalysts.
• Fine Chemical Production: Employed in the multi-step synthesis of complex fragrance molecules, flavors, and advanced material precursors.
• Academic & Contract Research: A valuable reagent for methodological studies in organic chemistry and for custom synthesis projects in CROs (Contract Research Organizations).

Basic Information

Product Name	Cyclopentanecarbonitrile, 2-(Acetyloxy)-1-Methyl-, (1R,2R)- (9Ci)
CAS No.	682746-81-2
Molecular Formula	C9H13NO2
Molecular Weight	167.21 g/mol
Synonyms	(1R,2R)-2-(Acetyloxy)-1-Methylcyclopentanecarbonitrile; (1R,2R)-1-Methyl-2-(acetyloxy)cyclopentanecarbonitrile; trans-2-(Acetyloxy)-1-Methylcyclopentanecarbonitrile; (1R,2R)-1-Methyl-2-acetoxycyclopentanecarbonitrile; Cyclopentanecarbonitrile, 2-(acetyloxy)-1-methyl-, (1R,2R)-rel-; (1R,2R)-2-Acetoxy-1-methylcyclopentanecarbonitrile
EINECS	Contact for details

Quality Control

Our production of Cyclopentanecarbonitrile, 2-(Acetyloxy)-1-Methyl-, (1R,2R)- adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity, critical for sensitive synthetic applications. Each lot is characterized by advanced analytical techniques including chiral HPLC, NMR, and GC/MS to confirm identity, chemical purity, and stereochemical integrity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. Our quality management system supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled and stored away from strong acids and incompatible organic solvents. Keep the container tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.