Description

1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid, 2-[(4-Thiocyanatophenyl)Methyl]- is a sophisticated bifunctional chelator, a key intermediate in the synthesis of advanced diagnostic and therapeutic agents. Its core value lies in its ability to form exceptionally stable complexes with a variety of metal ions, particularly lanthanides and radiometals, which is critical for precision applications. This compound is essential for researchers and manufacturers in the fields of molecular imaging, targeted radiotherapy, and advanced biomedical research who require high-purity, reliable building blocks for complex ligand systems.

Application

• Synthesis of MRI Contrast Agents: Acts as a precursor for gadolinium-based contrast agents used in magnetic resonance imaging (MRI) to enhance image clarity and diagnostic accuracy.
• Radiopharmaceutical Development: Serves as a crucial chelator for binding radioisotopes (e.g., 68Ga, 177Lu, 90Y) in the production of targeted diagnostic and therapeutic radiopharmaceuticals for oncology.
• Bifunctional Chelator (BFC) Conjugation: The thiocyanatophenyl group provides a reactive site for conjugation to biomolecules like antibodies, peptides, or proteins, creating targeted molecular probes.
• Lanthanide Luminescence Probes: Used to create highly stable luminescent complexes for time-resolved fluorescence assays and cellular imaging applications.
• Catalysis Research: Employed as a ligand to create metal complexes for studying catalytic processes in organic and inorganic chemistry.
• Chemical Sensor Development: Utilized in the design of selective sensors for metal ion detection due to its high affinity and specificity.

Basic Information

Item	Details
Product Name	1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid, 2-[(4-Thiocyanatophenyl)Methyl]-
CAS No.	681485-27-8
Molecular Formula	C26H34N6O8S
Molecular Weight	590.65 g/mol
Synonyms	DO3A-SCN; p-SCN-Bn-DO3A; 2-(4-Isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid; 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 2-[(4-isothiocyanatophenyl)methyl]-; SCN-Bn-DO3A; Bifunctional DO3A chelator; 2-(p-Isothiocyanatobenzyl)-DO3A; 4-Isothiocyanatobenzyl-DO3A
EINECS	Contact for details

Quality Control

Our 1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid, 2-[(4-Thiocyanatophenyl)Methyl]- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive biomedical applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters to support your research and development or cGMP manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Functional Group (NCS)	Confirmed

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.