Description

2,3-Difluoro-n-Methoxy-n-Methylbenzamide is a high-purity, specialized fluorinated aromatic amide building block. This compound is valued for its role as a key intermediate in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is essential for medicinal chemists and process development scientists working on novel active ingredients, where its unique difluoro and methoxy substitution pattern enables precise modulation of biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, anti-cancer agents, and central nervous system (CNS) drugs.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and pesticides, leveraging the fluorine atoms to enhance metabolic stability and bioavailability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of specialty polymers and advanced organic electronic materials.
• Chemical Synthesis Reagent: Employed in organic synthesis for constructing complex benzamide scaffolds, facilitating Suzuki couplings, amide bond formations, and other cross-coupling reactions.
• Life Science Research: Utilized as a biochemical tool or probe in academic and industrial research to study enzyme mechanisms and protein-ligand interactions.

Basic Information

Product Name	2,3-Difluoro-n-Methoxy-n-Methylbenzamide
CAS No.	680610-58-6
Molecular Formula	C10H11F2NO2
Molecular Weight	215.20 g/mol
Synonyms	2,3-Difluoro-N-methoxy-N-methylbenzamide; N-Methoxy-N-methyl-2,3-difluorobenzamide; 2,3-Difluorobenzoic acid N-methoxy-N-methylamide; N-Methoxy-N,2,3-trifluorobenzamide; Benzamide, 2,3-difluoro-N-methoxy-N-methyl-; 680610-58-6; Amide coupling reagent derivative; Fluorinated Weinreb amide analog
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-n-Methoxy-n-Methylbenzamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements for research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability, consistency, and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.