Description

Ibalizumab is a humanized monoclonal antibody designed to target the CD4 receptor on T-cells. This product is critical for advanced research and development in the field of immunology and virology, offering a targeted mechanism of action. It is primarily utilized by pharmaceutical researchers, biotechnology companies, and academic institutions engaged in the study of HIV-1 infection and other immune-mediated conditions.

Application

• HIV-1 Research: Investigation of viral entry inhibition and mechanism of action studies.
• Immunology Studies: Exploration of T-cell function, signaling, and immune modulation.
• Biopharmaceutical Development: Serves as a reference standard or key intermediate in the development of therapeutic antibodies.
• Preclinical & Clinical Research: Used in assay development, pharmacokinetic/pharmacodynamic modeling, and safety evaluation studies.
• Cell Biology: Tool for studying CD4 receptor interactions and downstream cellular effects.

Basic Information

Product Name	Ibalizumab
CAS No.	680188-33-4
Molecular Formula	C6440H9916N1700O2016S46
Molecular Weight	Approx. 145 kDa
Synonyms	TNX-355; Hu5A8; Anti-CD4 Monoclonal Antibody; Ibalizumab-uiyk; Trogarzo (brand name); Monoclonal Antibody to CD4; CD4 Antagonist; TMB-355; Humanized IgG4 Anti-CD4 Antibody
EINECS	Contact for details

Quality Control

Our Ibalizumab is produced and tested under stringent quality management systems. Each batch is subjected to a comprehensive battery of analytical tests to ensure identity, purity, potency, and safety, meeting the exacting standards required for research and development applications. Certificates of Analysis (COA) detailing specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under appropriate conditions to prevent degradation. For long-term storage, consider aliquoting and freezing at -20°C or below.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Identification (HPLC/MS)	Conforms to reference standard
Purity (SDS-PAGE)	> 95%
Purity (SEC-HPLC)	> 98% (Monomer)
Assay (ELISA/SPR)	90% - 110% of stated potency
Endotoxin	< 1.0 EU/mg
Protein Concentration	As per COA
Solubility	Soluble in PBS or suitable aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.