Description

4-Bromo-2-Fluoro-5-Methylphenylboronic Acid is a high-purity boronic acid derivative, a critical building block in modern synthetic chemistry. Its value lies in its role as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly in the development of active pharmaceutical ingredients (APIs) and functional organic molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those containing complex, fluorinated biphenyl or heterobiaryl scaffolds.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the specific halogen and fluorine substitution pattern imparts desired biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or building block for constructing organic electronic materials, such as those used in OLEDs (Organic Light-Emitting Diodes) and semiconductors.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for catalysis or as a core structure in metal-organic frameworks (MOFs).
• Chemical Biology & Diagnostics: Utilized in the synthesis of probes and sensors that leverage boronic acid chemistry for saccharide recognition or other bio-orthogonal applications.
• Custom Synthesis & Contract Manufacturing: A vital reagent for fine chemical and custom synthesis organizations serving the life sciences industry.

Basic Information

Product Name	4-Bromo-2-Fluoro-5-Methylphenylboronic Acid
CAS No.	677777-57-0
Molecular Formula	C7H7BBrFO2
Molecular Weight	232.85 g/mol
Synonyms	(4-Bromo-2-fluoro-5-methylphenyl)boronic acid; 2-Fluoro-5-methyl-4-bromophenylboronic acid; 4-Bromo-2-fluoro-5-methylbenzeneboronic acid; B-(4-Bromo-2-fluoro-5-methylphenyl)boronic acid; 677777-57-0; 4-Br-2-F-5-MeC6H2B(OH)2
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Fluoro-5-Methylphenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high chemical purity and identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring stringent material consistency, from R&D to scale-up production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is easily oxidized; for long-term storage, consider keeping under an inert atmosphere (e.g., nitrogen or argon) to maintain optimal purity and shelf life. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.