Description

5-Iodo-2-Methoxybenzonitrile is a versatile halogenated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring iodine, methoxy, and nitrile functional groups, makes it a valuable precursor for constructing complex molecules via cross-coupling and functional group transformations. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Serves as a building block for developing novel herbicides, fungicides, and insecticides, leveraging the reactivity of the iodine substituent.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for transition metal catalysis, where the methoxy and nitrile groups can influence metal coordination.
• Material Science Precursor: Employed in the synthesis of organic electronic materials and liquid crystals, where its aromatic core and substituents modify electronic properties.
• Cross-Coupling Reactions: The iodine atom is an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings to form biaryl and other extended systems.
• Functional Group Transformation: The nitrile group can be hydrolyzed to carboxylic acids, reduced to amines, or serve as a handle for heterocycle formation (e.g., tetrazoles).

Basic Information

Product Name	5-Iodo-2-Methoxybenzonitrile
CAS No.	677777-44-5
Molecular Formula	C8H6INO
Molecular Weight	259.05 g/mol
Synonyms	2-Methoxy-5-iodobenzonitrile; 5-Iodo-2-methoxybenzonitrile; 2-Cyano-4-iodoanisole; 4-Iodo-2-methoxybenzonitrile; Benzonitrile, 5-iodo-2-methoxy-; 5-Iodo-o-anisonitrile
EINECS	Contact for details

Quality Control

Our 5-Iodo-2-Methoxybenzonitrile is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as identity, assay, and impurity profiles. Our quality system is designed to meet the stringent requirements of our partners in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.