Description

2-Pyrrolidinecarbonitrile, 1-(Chloroacetyl)-5-Methyl-, (2S,5S)- (9Ci) is a high-purity, stereochemically defined chiral intermediate of significant importance in modern synthetic chemistry. Its value lies in its role as a key building block for the synthesis of complex, biologically active molecules, particularly in the pharmaceutical sector. This compound is essential for research and development chemists and process scale-up teams working on novel active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• As a critical chiral synthon in the asymmetric synthesis of pharmaceutical candidates, particularly for central nervous system (CNS) and antiviral drugs.
• Building block for the development of protease inhibitors and other enzyme-targeted therapeutics.
• Intermediate in the research and production of advanced agrochemicals with specific stereochemical requirements for enhanced efficacy.
• Precursor for ligands and catalysts used in stereoselective transformations.
• Starting material in the synthesis of functionalized pyrrolidine derivatives for material science applications.
• Use in academic and industrial R&D for exploring new synthetic methodologies and compound libraries.

Basic Information

Product Name	2-Pyrrolidinecarbonitrile, 1-(Chloroacetyl)-5-Methyl-, (2S,5S)- (9Ci)
CAS No.	676561-06-1
Molecular Formula	C8H11ClN2O
Molecular Weight	186.64 g/mol
Synonyms	(2S,5S)-1-(Chloroacetyl)-5-methylpyrrolidine-2-carbonitrile; 1-(Chloroacetyl)-5-methyl-(2S,5S)-pyrrolidine-2-carbonitrile; (2S,5S)-1-Chloroacetyl-5-methyl-2-cyanopyrrolidine; (2S,5S)-5-Methyl-1-(chloroacetyl)pyrrolidine-2-carbonitrile; (2S,5S)-N-Chloroacetyl-5-methylprolinenitrile; (2S,5S)-1-(2-Chloroacetyl)-5-methylpyrrolidine-2-carbonitrile
EINECS	Contact for details

Quality Control

Our 2-Pyrrolidinecarbonitrile, 1-(Chloroacetyl)-5-Methyl-, (2S,5S)- (9Ci) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. The product undergoes rigorous analytical testing, including chiral HPLC, to confirm stereochemical purity and identity. Certificates of Analysis (COA) detailing specific results for each batch are available upon request, supporting compliance with cGMP and other relevant regulatory frameworks for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.