Description

2- Iodine -6- Fluoro Formamide is a halogenated formamide derivative, a key building block in advanced organic synthesis. Its unique structure, featuring both iodine and fluorine substituents, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the introduction of halogen atoms can enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for the development of specialty polymers and liquid crystals, where fluorine and iodine can modify material properties.
• Cross-Coupling Reactions: The iodine moiety makes it a valuable substrate for palladium-catalyzed cross-coupling reactions, such as Suzuki or Sonogashira couplings, to form carbon-carbon bonds.
• Fluorination Reagent Precursor: Can be utilized to introduce fluorine atoms into target molecules, a common strategy in modern drug design to improve metabolic stability and membrane permeability.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and molecular probes for biochemical and diagnostic research applications.

Basic Information

Product Name	2- Iodine -6- Fluoro Formamide
CAS No.	676445-27-5
Molecular Formula	C7H4FINO
Molecular Weight	279.02 g/mol
Synonyms	2-Iodo-6-fluoroformamide; 6-Fluoro-2-iodobenzamide; 2-Iodo-6-fluorobenzamide; Benzamide, 2-iodo-6-fluoro-; (2-Iodo-6-fluorophenyl)formamide; o-Iodo-o'-fluorobenzamide; AI3-03943; ZINC000004057756
EINECS	Contact for details

Quality Control

Our 2- Iodine -6- Fluoro Formamide is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and support our products with a detailed Certificate of Analysis (COA), which includes results from HPLC, NMR, and mass spectrometry. Our quality systems are designed to meet the stringent requirements of cGMP for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.