Description

3-Iodo-1-Tosyl-1H-Indole-5-Carbonitrile is a high-value, multi-functional indole derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its unique structure, featuring both electron-withdrawing and bulky protecting groups, makes it an indispensable building block for constructing complex heterocyclic frameworks. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting kinase inhibition and other biological pathways.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with unique modes of action.
• Material Science: Serves as a building block for organic semiconductors, liquid crystals, and photoactive polymers.
• Chemical Biology: Employed as a molecular probe or a tag in bioconjugation chemistry due to its reactive iodine moiety.
• Academic & Contract Research: Essential for methodological development in cross-coupling reactions and indole chemistry.
• Scale-Up Synthesis: Supports process chemistry for the pilot and commercial-scale production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	3-Iodo-1-Tosyl-1H-Indole-5-Carbonitrile
CAS No.	676273-39-5
Molecular Formula	C16H11IN2O2S
Molecular Weight	438.24 g/mol
Synonyms	5-Cyano-3-iodo-1-tosyl-1H-indole; 1H-Indole-5-carbonitrile, 3-iodo-1-[(4-methylphenyl)sulfonyl]-; 3-Iodo-1-(p-toluenesulfonyl)-1H-indole-5-carbonitrile; 3-Iodo-1-tosylindole-5-carbonitrile; 3-Iodo-1-tosyl-1H-indole-5-CN; 676273-39-5; 1-Tosyl-3-iodoindole-5-carbonitrile
EINECS	Contact for details

Quality Control

Every batch of 3-Iodo-1-Tosyl-1H-Indole-5-Carbonitrile is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. Our standard offering meets typical research-grade specifications, with purity levels exceeding 95% (HPLC). A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat and incompatible materials. This product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.