Description

Naptumomab Estafenatox CAS NO 676258-98-3 is a recombinant fusion protein designed for targeted cancer therapy, representing a significant advancement in the field of biopharmaceuticals. This product is engineered to deliver a potent cytotoxic agent specifically to tumor cells expressing the 5T4 oncofetal antigen, minimizing damage to healthy tissues. It is a critical reagent and active pharmaceutical ingredient (API) for research institutions, biotechnology companies, and pharmaceutical manufacturers engaged in the development and production of next-generation immunotherapies and targeted cancer treatments.

Application

• Active Pharmaceutical Ingredient (API) in the formulation of targeted cancer therapeutics.
• Pre-clinical and Clinical Research for studying mechanisms of action, efficacy, and safety profiles of immunotoxin-based therapies.
• Bioconjugation and Drug Development as a model compound for developing novel antibody-drug conjugates (ADCs).
• Process Development & Scale-up for optimizing manufacturing processes in biopharmaceutical production.
• Reference Standard for quality control, assay validation, and regulatory submissions.
• Oncology Target Validation in cellular and animal models to confirm the role of the 5T4 antigen.

Basic Information

Product Name	Naptumomab Estafenatox
CAS No.	676258-98-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Naptumomab Estafenatox; Anti-5T4 Recombinant Immunotoxin; 5T4-targeted Immunoconjugate; ABR-217620; Naptumomab Estafenatox (USAN); Recombinant Fusion Protein scFv(anti-5T4)-PE38; 5T4(scFv)-PE38 Immunotoxin
EINECS	Contact for details

Quality Control

Our Naptumomab Estafenatox is manufactured and controlled under a strict quality management system. Each batch is subjected to a comprehensive suite of analytical tests to ensure identity, purity, potency, and safety, adhering to relevant ICH guidelines. Specifications are designed to meet the stringent requirements for biopharmaceutical development. A detailed Certificate of Analysis (COA) documenting purity, biological activity, endotoxin levels, and sterility (where applicable) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store frozen at -20°C to -80°C for long-term stability. For short-term storage, maintain at 2-8°C. This product is hygroscopic (moisture-sensitive). Avoid repeated freeze-thaw cycles. Aliquot into working volumes upon first thaw to preserve stability.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Identification (SDS-PAGE / Mass Spec)	Conforms to reference standard
Purity (SEC-HPLC / SDS-PAGE)	≥ 95%
Protein Content (UV Absorbance / BCA)	As per COA
Biological Activity (Cell-based Assay)	As per COA
Endotoxin (LAL Test)	< 1.0 EU/mg
Sterility (Membrane Filtration)	Sterile (for sterile-filtered grades)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.