Description

D-Mannitol, 2-(Acetylamino)-2-Deoxy-6-o-[(1,1-Dimethylethyl)Diphenylsilyl]-1,3:4,5-Bis-o-(1-Methylethylidene)- is a highly functionalized, protected mannitol derivative, serving as a critical advanced pharmaceutical intermediate in complex organic synthesis. Its value lies in providing a chiral scaffold with orthogonal protecting groups, enabling precise, multi-step chemical transformations. This compound is essential for researchers and manufacturers in pharmaceutical development, particularly for synthesizing novel carbohydrate-based therapeutics, nucleoside analogs, and complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of complex drug candidates, including antiviral and anticancer agents.
• Carbohydrate Chemistry Research: Used in academic and industrial R&D for studying glycosylation reactions and developing new synthetic methodologies.
• Nucleoside & Nucleotide Synthesis: Serves as a precursor or protected intermediate in the production of modified nucleosides for medicinal chemistry.
• Glycoconjugate Development: Employed in the creation of glycopeptides, glycolipids, and other biologically active conjugates.
• Process Chemistry: Used in scale-up and optimization studies for the commercial production of fine chemicals and APIs.
• Protecting Group Strategy: The tert-butyldiphenylsilyl (TBDPS) and isopropylidene groups allow for selective deprotection, facilitating complex multi-step syntheses.

Basic Information

Item	Detail
Product Name	D-Mannitol, 2-(Acetylamino)-2-Deoxy-6-o-[(1,1-Dimethylethyl)Diphenylsilyl]-1,3:4,5-Bis-o-(1-Methylethylidene)-
CAS No.	676227-14-8
Molecular Formula	C31H45NO6Si
Molecular Weight	555.78 g/mol
Synonyms	1,3:4,5-Di-O-isopropylidene-2-acetamido-2-deoxy-6-O-(tert-butyldiphenylsilyl)-D-mannitol; 2-Acetamido-2-deoxy-1,3:4,5-di-O-isopropylidene-6-O-(tert-butyldiphenylsilyl)-D-mannitol; 6-O-(tert-Butyldiphenylsilyl)-1,3:4,5-di-O-isopropylidene-2-acetamido-2-deoxy-D-mannitol; TBDPS-protected D-mannitol derivative; Protected N-Acetyl-D-mannosamine derivative; Advanced Mannitol Intermediate; Chiral Silyl Ether Intermediate
EINECS	Contact for details

Quality Control

Our D-Mannitol derivative is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.