Description

n-((2R,3R,4S,5R)-6-((tert-Butyldiphenylsilyl)Oxy)-1,3,4,5-Tetrahydroxyhexan-2-Yl)Acetamide is a high-purity, stereochemically defined carbohydrate derivative, serving as a critical protected intermediate in advanced organic synthesis. Its primary value lies in enabling the precise construction of complex bioactive molecules, particularly in pharmaceutical research and development. This compound is essential for scientists and manufacturers in the life sciences sector who require reliable, high-quality building blocks for synthesizing nucleoside analogs, glycopeptides, and other sophisticated therapeutic candidates.

Application

• Pharmaceutical Intermediate: A key protected synthon for the synthesis of novel nucleoside and nucleotide analogs with potential antiviral or anticancer activity.
• Glycochemistry Research: Used in the study and synthesis of complex oligosaccharides, glycoconjugates, and glycomimetics due to its defined stereochemistry and protective groups.
• Antibiotic Development: Serves as a building block in the research and production of advanced glycopeptide antibiotics and related compounds.
• Bioconjugation: Facilitates the site-specific modification of proteins, peptides, and other biomolecules for drug delivery and diagnostic applications.
• Process Chemistry: Employed in scale-up and route development for active pharmaceutical ingredients (APIs) requiring sophisticated carbohydrate motifs.
• Chemical Biology Probes: Used to create labeled or modified sugar derivatives for investigating biological pathways and mechanisms.

Basic Information

Product Name	n-((2R,3R,4S,5R)-6-((tert-Butyldiphenylsilyl)Oxy)-1,3,4,5-Tetrahydroxyhexan-2-Yl)Acetamide
CAS No.	676227-13-7
Molecular Formula	C25H35NO6Si
Molecular Weight	473.64 g/mol
Synonyms	1,3,4,5-Tetrahydroxy-6-[(tert-butyldiphenylsilyl)oxy]hexan-2-ylacetamide; N-Acetyl-6-O-(tert-butyldiphenylsilyl)-D-glucopyranosylamine; 6-O-TBDPS-N-acetyl-D-glucosamine derivative; TBDPS-protected N-acetyl glucosamine intermediate; (2R,3R,4S,5R)-2-(Acetylamino)-6-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1,3,4,5-hexanetetrol; Acetamide, N-[(2R,3R,4S,5R)-6-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1,3,4,5-tetrahydroxy-2-hexanyl]-
EINECS	Contact for details

Quality Control

Our n-((2R,3R,4S,5R)-6-((tert-Butyldiphenylsilyl)Oxy)-1,3,4,5-Tetrahydroxyhexan-2-Yl)Acetamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and process chemistry. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity	≥ 99.0% de (by chiral HPLC)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.