Description

3-(2,2,2-Trifluoroacetylamino)Thiophene-2-Carboxylic Acid Amide is a high-purity, advanced pharmaceutical intermediate characterized by its unique trifluoroacetyl-protected amino thiophene scaffold. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting a range of therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of new drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex drug molecules, especially those containing thiophene and trifluoromethyl motifs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• API Development: A crucial precursor in the multi-step synthesis of potential Active Pharmaceutical Ingredients (APIs).
• Bioconjugation & Probe Synthesis: The reactive amide and protected amine functionalities make it suitable for creating biochemical probes and conjugates.
• Agrochemical Research: Potential intermediate in the development of novel agrochemicals and pesticides.
• Material Science: Exploration of its use in the synthesis of specialty polymers or organic electronic materials.

Basic Information

Item	Details
Product Name	3-(2,2,2-Trifluoroacetylamino)Thiophene-2-Carboxylic Acid Amide
CAS No.	676119-37-2
Molecular Formula	C7H5F3N2O2S
Molecular Weight	238.19 g/mol
Synonyms	3-[(2,2,2-Trifluoroacetyl)amino]-2-thiophenecarboxamide; 3-(Trifluoroacetylamino)thiophene-2-carboxamide; 2-Thiophenecarboxamide, 3-[(2,2,2-trifluoroacetyl)amino]-; N-(2-Carbamoylthiophen-3-yl)-2,2,2-trifluoroacetamide; 3-(2,2,2-Trifluoroacetamido)thiophene-2-carboxamide; TFA-Thiophene-amide; CAS 676119-37-2
EINECS	Contact for details

Quality Control

Our 3-(2,2,2-Trifluoroacetylamino)Thiophene-2-Carboxylic Acid Amide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.