Description

Methyl 1-Benzyl-3-(tert-Butoxycarbonylamino)Pyrrolidine-3-Carboxylate is a high-purity, protected pyrrolidine derivative serving as a critical chiral building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring precise stereochemistry and functional group compatibility in complex molecule construction. It is primarily utilized in the pharmaceutical industry for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of peptidomimetics and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, especially for central nervous system (CNS) and metabolic disorder targets.
• Peptidomimetic Synthesis: Used to construct constrained peptide analogs and protease inhibitors by incorporating the rigid pyrrolidine scaffold.
• Asymmetric Synthesis: Serves as a starting material or intermediate for catalysts and ligands used in enantioselective transformations.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs due to its versatile protected amine and ester functionalities.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production of complex molecules.
• Academic & R&D Laboratories: Used in methodological development and the synthesis of novel chemical entities for biological screening.

Basic Information

Item	Detail
Product Name	Methyl 1-Benzyl-3-(tert-Butoxycarbonylamino)Pyrrolidine-3-Carboxylate
CAS No.	675834-17-0
Molecular Formula	C19H28N2O4
Molecular Weight	348.44 g/mol
Synonyms	1-Benzyl-3-[(tert-butoxycarbonyl)amino]pyrrolidine-3-carboxylic acid methyl ester; Methyl 3-[(tert-butoxycarbonyl)amino]-1-benzyl-3-pyrrolidinecarboxylate; 1-Benzyl-3-(Boc-amino)pyrrolidine-3-carboxylic acid methyl ester; Boc-3-amino-1-benzyl-pyrrolidine-3-carboxylic acid methyl ester; (3R)- or (3S)-1-Benzyl-3-[(tert-butoxycarbonyl)amino]pyrrolidine-3-carboxylic acid methyl ester (enantiomers); 675834-17-0; tert-Butyl N-(1-benzyl-3-methoxycarbonyl-3-pyrrolidinyl)carbamate
EINECS	Contact for details

Quality Control

Our Methyl 1-Benzyl-3-(tert-Butoxycarbonylamino)Pyrrolidine-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with ICH guidelines and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee (for enantiomerically pure grade)
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.