Description

Fmoc-Nh-Peg12-Ch2Cooh is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring an amine-reactive Fmoc-protected amino group and a carboxylic acid terminus. This compound is specifically engineered for the controlled synthesis and modification of biomolecules, offering a long, flexible, and hydrophilic PEG spacer to enhance solubility and reduce immunogenicity. It is a critical reagent for researchers and manufacturers in pharmaceutical development, bioconjugation, and proteomics, enabling the creation of advanced drug delivery systems, diagnostic agents, and peptide-based therapeutics.

Application

• Bioconjugation and Linker Chemistry: Serves as a versatile heterobifunctional crosslinker for attaching peptides, proteins, or other bioactive molecules to surfaces, nanoparticles, or other macromolecules.
• Peptide Synthesis (SPPS): Used in solid-phase peptide synthesis as a building block to introduce a long, solubilizing PEG spacer chain into peptide sequences, improving yield and handling.
• ADC (Antibody-Drug Conjugate) Development: Facilitates the construction of stable, cleavable, or non-cleavable linkers between monoclonal antibodies and cytotoxic payloads.
• PEGylation Reagent: Enables site-specific PEGylation of therapeutic proteins and peptides to prolong circulation half-life and improve stability.
• Diagnostic Probe Synthesis: Used to conjugate targeting ligands (e.g., antibodies, peptides) to reporter molecules (e.g., dyes, chelators) for imaging and diagnostic applications.
• Hydrogel and Biomaterial Fabrication: Acts as a functional monomer or crosslinking agent in the creation of biocompatible hydrogels for tissue engineering and controlled release.
• Surface Functionalization: Used to modify surfaces (e.g., gold, silica, polymers) with a carboxylic acid group via a long PEG tether for subsequent biomolecule immobilization.

Basic Information

Product Name	Fmoc-Nh-Peg12-Ch2Cooh
CAS No.	675606-79-8
Molecular Formula	C58H105N3O28
Molecular Weight	1292.5 g/mol
Synonyms	Fmoc-N-amido-PEG12-acid; Fmoc-NH-PEG12-COOH; 22-Aza-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxa-39-(9H-fluoren-9-ylmethoxycarbonylamino)hentetracontanoic Acid; N-α-Fmoc-12-amino-4,7,10,13,16,19,22,25,28,31,34-undecaoxa-1-azapentatriacontan-35-oic Acid; Fmoc-12-amino-4,7,10,13,16,19,22,25,28,31,34-undecaoxa-1-azapentatriacontan-35-oic Acid; Fmoc-N-PEG12-acid; Fmoc-AEEA-PEG11-COOH
EINECS	Contact for details

Quality Control

Our Fmoc-Nh-Peg12-Ch2Cooh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting critical parameters such as assay, related substances, and residual solvents. Our quality commitment supports applications requiring GMP-grade materials for preclinical and clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This material is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, keep containers in a dry, inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white waxy solid or powder
Identification (HPLC/MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC, 214 nm)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.