Description

n-{4-[4-(2,3-Dichlorophenyl)-Piperazin-1-Yl]-trans-But-2-Enyl}-4-(Pyridin-2-Yl)Benzamide Dihydrochloride Hydrate is a high-purity, non-racemic chemical building block and research compound of significant interest in medicinal chemistry. Its complex molecular architecture, featuring a piperazine linker and a trans-but-2-enyl spacer, makes it a valuable intermediate for the synthesis of novel pharmacologically active molecules. This compound is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of central nervous system (CNS) and receptor-targeted therapeutics.

Application

• Pharmaceutical Research & Development (R&D): Serves as a key synthetic intermediate or reference standard in the discovery and optimization of new drug candidates, particularly those targeting dopamine and serotonin receptor systems.
• Medicinal Chemistry: Used as a sophisticated scaffold for structure-activity relationship (SAR) studies to explore and modulate biological activity.
• Biochemical Research: Employed as a ligand or tool compound in in vitro assays to study receptor binding affinity, selectivity, and functional activity.
• Fine Chemical Synthesis: Acts as a premium building block for the custom synthesis of complex, high-value specialty chemicals for advanced research applications.
• Reference Standard: Provides a characterized compound for analytical method development, validation, and quality control in research settings.

Basic Information

Product Name	n-{4-[4-(2,3-Dichlorophenyl)-Piperazin-1-Yl]-trans-But-2-Enyl}-4-(Pyridin-2-Yl)Benzamide Dihydrochloride Hydrate
CAS No.	675599-62-9
Molecular Formula	C26H27Cl2N4O • 2HCl • xH2O
Molecular Weight	Contact for details
Synonyms	trans-4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]-N-[4-(pyridin-2-yl)benzoyl]but-2-en-1-amine dihydrochloride hydrate; 675599-62-9; 4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]-2-buten-1-yl 4-(2-Pyridinyl)benzamide dihydrochloride hydrate; SB-277011-A Dihydrochloride Hydrate (common research alias); SB277011A Dihydrochloride Hydrate; DDPH derivative; Dopamine D3 Receptor Antagonist (functional class)
EINECS	Contact for details

Quality Control

Our n-{4-[4-(2,3-Dichlorophenyl)-Piperazin-1-Yl]-trans-But-2-Enyl}-4-(Pyridin-2-Yl)Benzamide Dihydrochloride Hydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR, and mass spectrometry for structural confirmation, to ensure it meets the exacting standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee (trans-isomer)
Water Content (KF)	Contact for details
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.