Description

2-Bromomethyl-4-Fluorophenylboronic Acid Neopentyl Glycol Ester is a high-value, advanced pharmaceutical intermediate and versatile synthetic building block. This compound is specifically engineered to provide a protected boronic acid functionality, offering enhanced stability and reactivity for complex cross-coupling reactions. It is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel molecular architectures.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of complex biaryl and heterobiaryl structures.
• Pharmaceutical Intermediate: Used in the research and production of active pharmaceutical ingredients (APIs), particularly those containing fluorinated and brominated aromatic motifs.
• Agrochemical Synthesis: Serves as a building block for novel herbicides, fungicides, and insecticides requiring specific halogenated aromatic cores.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis.
• Material Science Research: Utilized in the synthesis of organic electronic materials, such as those for OLEDs and semiconductors.
• Chemical Biology Probes: Acts as a precursor for tagged molecules used in proteomics and diagnostic assay development.

Basic Information

Product Name	2-Bromomethyl-4-Fluorophenylboronic Acid Neopentyl Glycol Ester
CAS No.	673456-16-1
Molecular Formula	C₁₄H₁₉BBrFO₂
Molecular Weight	329.02 g/mol
Synonyms	4-Fluoro-2-(bromomethyl)benzeneboronic Acid Neopentyl Glycol Ester; 2-(Bromomethyl)-4-fluorophenylboronic Acid Pinacol Ester (common misnomer); (4-Fluoro-2-(bromomethyl)phenyl)boronic Acid Neopentyl Ester; B-(4-Fluoro-2-(bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane; 673456-16-1; 2-Bromomethyl-4-fluorobenzeneboronic Acid Neopentyl Glycol Ester
EINECS	Contact for details

Quality Control

Every batch of 2-Bromomethyl-4-Fluorophenylboronic Acid Neopentyl Glycol Ester is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA), including results from HPLC, NMR, and other relevant analytical techniques, is supplied with each shipment to guarantee traceability, purity, and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.