Description

1-Naphthalenebutanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-, (αs)- is a specialized, high-purity Fmoc-protected amino acid derivative designed for advanced organic synthesis. This compound is critical for researchers and manufacturers requiring precise molecular construction, particularly in the development of complex bioactive molecules. It serves as a key chiral building block for pharmaceutical R&D, peptide synthesis, and the creation of novel chemical entities in life sciences.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the sequential assembly of peptides, enabling the incorporation of a naphthylalanine analog into peptide chains.
• Pharmaceutical Intermediate: Used in the research and development of new drug candidates, particularly those targeting protein-protein interactions or requiring hydrophobic aromatic side chains.
• Bioconjugation and Probe Development: Employed to synthesize labeled peptides or protein conjugates for diagnostic assays, imaging probes, and biochemical research tools.
• Combinatorial Chemistry: Serves as a valuable building block in libraries for high-throughput screening to discover new lead compounds with therapeutic potential.
• Academic and Industrial Research: Essential for synthetic chemistry studies exploring novel amino acid structures, peptide mimetics, and foldamers.

Basic Information

Product Name	1-Naphthalenebutanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-, (αs)-
CAS No.	672964-72-6
Molecular Formula	C₂₉H₂₇NO₄
Molecular Weight	453.53 g/mol
Synonyms	Fmoc-1-Nal-OH; Fmoc-1-naphthylalanine; Fmoc-1-Naphthyl-Ala-OH; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(naphthalen-1-yl)propanoic acid; N-α-Fmoc-1-naphthylalanine; Fmoc-Nal(1)-OH; 1-Naphthylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, (αS)-; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-naphthylalanine
EINECS	Contact for details

Quality Control

Every batch of 1-Naphthalenebutanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-, (αs)- is manufactured and tested under strict quality management systems to ensure the highest standards of purity and consistency required for sensitive synthetic applications. Our products undergo rigorous quality testing, including chiral purity verification, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing specific batch results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (S-isomer)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.