Description

(2S)-2-(Fmoc-Amino)-4-(3-Quinolyl)Butanoic Acid is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is a critical building block in solid-phase peptide synthesis (SPPS), where the Fmoc protecting group offers orthogonal deprotection under mild basic conditions. It is essential for researchers and manufacturers in pharmaceutical development, particularly for creating complex peptides and peptidomimetics with specific quinolyl side-chain functionalities for targeted biological activity.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid for the automated synthesis of custom peptides.
• Pharmaceutical Research & Development: Used in the discovery and development of novel therapeutic peptides, especially those targeting specific protein-protein interactions.
• Peptidomimetic Design: Incorporates the unique 3-quinolyl moiety to mimic protein structures and enhance metabolic stability or binding affinity in drug candidates.
• Chemical Biology Probes: Serves as a building block for creating labeled or modified peptides used in biochemical assays and diagnostic tool development.
• Academic Research: Employed in university and institutional labs for studying peptide structure, function, and synthesis methodologies.
• API Intermediate Manufacturing: Acts as a critical intermediate in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs) for preclinical and clinical trials.

Basic Information

Product Name	(2S)-2-(Fmoc-Amino)-4-(3-Quinolyl)Butanoic Acid
CAS No.	672964-70-4
Molecular Formula	C28H24N2O4
Molecular Weight	452.50 g/mol
Synonyms	Fmoc-3-(3-Quinolyl)-L-alanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(3-quinolyl)-L-alanine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(quinolin-3-yl)propanoic acid; Fmoc-L-3-(3-Quinolyl)alanine; Fmoc-3-Quinolyl-L-Ala-OH; Nα-Fmoc-3-(3-quinolyl)-L-alanine; 3-Quinolyl-L-alanine, N-Fmoc derivative; Fmoc-3-(3-Quinolyl)-DL-alanine (mixture)
EINECS	Contact for details

Quality Control

Every batch of (2S)-2-(Fmoc-Amino)-4-(3-Quinolyl)Butanoic Acid is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with stringent internal specifications for identity, purity, and chiral integrity, critical for peptide synthesis applications. A detailed Certificate of Analysis (COA) providing HPLC purity, chiral purity, NMR, and MS data is supplied with each shipment to guarantee reproducible performance in your research and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider desiccated conditions at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.