Description

5-Bromo-2-(trifluoromethoxy)anisole is a high-purity, multi-functional aromatic building block of significant interest in advanced organic synthesis. This compound matters for its unique molecular architecture, combining bromo, trifluoromethoxy, and methoxy substituents to enable precise structural modifications and introduce desirable physicochemical properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethoxy group can enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a building block for advanced electronic materials, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs), due to its aromatic core and halogen/fluorine substituents.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to form complex biaryl structures.
• Functional Polymer Monomer: Can be incorporated into specialty polymers to impart specific properties like chemical resistance, thermal stability, or unique optical characteristics.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Item	Details
Product Name	5-Bromo-2-(trifluoromethoxy)anisole
CAS No.	672948-65-1
Molecular Formula	C8H6BrF3O2
Molecular Weight	271.04 g/mol
Synonyms	1-Bromo-4-methoxy-2-(trifluoromethoxy)benzene; 4-Bromo-1-methoxy-2-(trifluoromethoxy)benzene; 2-Bromo-5-(trifluoromethoxy)anisole; 5-Bromo-2-(trifluoromethoxy)-1-methoxybenzene; Anisole, 5-bromo-2-(trifluoromethoxy)-; 5-Bromo-α,α,α-trifluoro-2-methoxyanisole
EINECS	Contact for details

Quality Control

Our production of 5-Bromo-2-(trifluoromethoxy)anisole adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All materials undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.