Description

1-Phenyl-2-(Di-Tert.-Butyl-Phosphino)-1H-Pyrrole is a specialized organophosphorus ligand with a pyrrole backbone, widely recognized for its utility in catalytic processes. Its value lies in its ability to form stable complexes with transition metals, enabling highly efficient and selective cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise control over reaction pathways to synthesize complex organic molecules.

Application

• Homogeneous Catalysis: As a key ligand in palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura, Negishi, and Buchwald-Hartwig aminations, for constructing C-C and C-N bonds.
• Pharmaceutical Intermediates: Enabling the synthesis of complex, high-value active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the development of novel pesticides, herbicides, and plant growth regulators.
• Material Science: Facilitating the creation of organic electronic materials, including polymers and small molecules for OLEDs and semiconductors.
• Asymmetric Synthesis: Potential use in designing chiral ligands for enantioselective catalysis to produce single-isomer compounds.
• Academic & Industrial R&D: A critical tool for method development and exploring new catalytic transformations in chemistry laboratories.

Basic Information

Product Name	1-Phenyl-2-(Di-Tert.-Butyl-Phosphino)-1H-Pyrrole
CAS No.	672937-61-0
Molecular Formula	C18H26NP
Molecular Weight	287.38 g/mol
Synonyms	1-Phenyl-2-(di-tert-butylphosphino)-1H-pyrrole; 2-(Di-tert-butylphosphino)-1-phenyl-1H-pyrrole; Di-tert-butyl(1-phenyl-1H-pyrrol-2-yl)phosphine; JohnPhos-type Pyrrole Ligand; P(t-Bu)2 Pyrrole Ligand; DTBP Pyrrole Ligand; (1-Phenyl-1H-pyrrol-2-yl)di-tert-butylphosphine
EINECS	Contact for details

Quality Control

Our production of 1-Phenyl-2-(Di-Tert.-Butyl-Phosphino)-1H-Pyrrole adheres to stringent quality protocols to ensure batch-to-batch consistency and high performance in sensitive catalytic applications. Each lot undergoes comprehensive analysis, including purity verification by HPLC and structural confirmation by NMR and IR spectroscopy. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity to oxidation and light, prolonged exposure to air or ambient light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.