Description

1-Pyrrolidineacetonitrile, 3-Amino-2,5-Dioxo-, (3S)- (9Ci) is a high-purity, chiral pyrrolidine derivative of significant interest in advanced organic synthesis. This compound serves as a sophisticated building block for the development of novel pharmaceuticals and bioactive molecules, particularly those targeting neurological and metabolic pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of complex heterocyclic compounds. The specific stereochemistry and functional groups present make it a valuable intermediate for creating enantiomerically pure active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for central nervous system (CNS) and enzyme inhibitor therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and library synthesis for lead optimization in drug discovery programs.
• Asymmetric Synthesis: Employed as a precursor or catalyst ligand in stereoselective reactions to construct complex molecular architectures.
• Bioconjugation & Probe Development: The amino and carbonyl functionalities allow for its use in creating biochemical probes and labeled compounds for diagnostic research.
• Agrochemical Research: Potential intermediate in the synthesis of novel, high-value crop protection agents with specific modes of action.
• Academic & Institutional R&D: Serves as a reference standard and starting material in university and government laboratory research focused on heterocyclic chemistry.

Basic Information

Product Name	1-Pyrrolidineacetonitrile, 3-Amino-2,5-Dioxo-, (3S)- (9Ci)
CAS No.	672883-37-3
Molecular Formula	C6H7N3O2
Molecular Weight	153.14 g/mol
Synonyms	(3S)-3-Amino-2,5-dioxo-1-pyrrolidineacetonitrile; (S)-3-Amino-2,5-dioxopyrrolidine-1-acetonitrile; 1-Pyrrolidineacetonitrile, 3-amino-2,5-dioxo-, (3S)-; (3S)-3-Amino-2,5-dioxo-1-pyrrolidineacetonitrile (9CI); 672883-37-3; (S)-3-Amino-2,5-dioxopyrrolidine-1-acetonitrile; 3-Amino-2,5-dioxo-1-pyrrolidineacetonitrile (S)-enantiomer
EINECS	Contact for details

Quality Control

Our production of 1-Pyrrolidineacetonitrile, 3-Amino-2,5-Dioxo-, (3S)- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and development. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all relevant specifications are provided with every shipment. We support compliance with global regulatory frameworks, and custom purity grades or specific impurity profiles can be discussed to meet your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under dry conditions to prevent decomposition. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.