Description

1-n-Fmoc-3-Pyrrolidinone is a key fluoromethyloxycarbonyl (Fmoc)-protected heterocyclic building block, essential for modern synthetic organic chemistry. Its primary value lies in enabling the controlled synthesis of complex pyrrolidine-based structures, which are privileged scaffolds in medicinal chemistry. This compound is critically needed by research scientists and process chemists in the pharmaceutical and biotechnology industries for the development of new active pharmaceutical ingredients (APIs) and novel chemical entities.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of drug candidates, particularly those targeting neurological and inflammatory diseases.
• Peptidomimetic Synthesis: Used to incorporate constrained pyrrolidine motifs into peptide backbones to enhance metabolic stability and biological activity.
• Solid-Phase Peptide Synthesis (SPPS): Serves as a protected amino acid derivative for the Fmoc-strategy, allowing for the sequential construction of complex peptides.
• Library Synthesis for Drug Discovery: Enables the rapid generation of diverse compound libraries for high-throughput screening (HTS) campaigns.
• Asymmetric Synthesis: Acts as a chiral building block for the construction of enantiomerically pure molecules in asymmetric catalysis.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes to study enzyme function and protein-protein interactions.

Basic Information

Product Name	1-n-Fmoc-3-Pyrrolidinone
CAS No.	672310-12-2
Molecular Formula	C19H17NO3
Molecular Weight	307.34 g/mol
Synonyms	1-(9-Fluorenylmethyloxycarbonyl)-3-pyrrolidinone; 1-Fmoc-3-pyrrolidinone; 3-Oxo-1-pyrrolidinecarboxylic acid 9H-fluoren-9-ylmethyl ester; 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]pyrrolidin-3-one; N-Fmoc-3-pyrrolidinone; Fmoc-3-pyrrolidone; 1-(Fmoc)pyrrolidin-3-one
EINECS	Contact for details

Quality Control

Our 1-n-Fmoc-3-Pyrrolidinone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. Due to its hygroscopic nature, the container should be kept tightly sealed in a desiccated environment to prevent moisture absorption, which can affect stability and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.