Description

Urantide CAS NO 669089-53-6 is a potent and selective peptide antagonist of the urotensin-II receptor (UT receptor). This compound is a critical research tool for investigating the urotensinergic system, which plays a significant role in cardiovascular regulation, renal function, and metabolic processes. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in drug discovery and basic scientific research related to hypertension, heart failure, and metabolic disorders.

Application

• Pharmacological Research: Used as a standard antagonist to study the physiological and pathophysiological roles of the urotensin-II system in vitro and in vivo.
• Drug Discovery & Development: Serves as a reference compound for screening and validating new UT receptor antagonists in cardiovascular and metabolic disease pipelines.
• Academic & Biomedical Studies: Essential for mechanistic studies in cellular signaling pathways involving the G-protein coupled UT receptor.
• Target Validation: Employed to confirm the specific involvement of the UT receptor in various disease models, aiding in target identification.
• Biochemical Assay Development: Used as a control in receptor binding assays and functional cellular assays to ensure assay reliability and reproducibility.

Basic Information

Product Name	Urantide
CAS No.	669089-53-6
Molecular Formula	C119H184N38O33S2
Molecular Weight	2635.1 g/mol
Synonyms	Urantide (peptide); H-Asp-c[Pen-Phe-Trp-Lys-Tyr-Cys]-Val-OH (cyclic 2-7 disulfide); UT receptor antagonist; Urotensin II receptor antagonist; Cyclo(penicillamine-Phe-Trp-Lys-Tyr-Cys)-Asp-Val; [Pen1,Phe2,Trp3,Lys4,Tyr5,Cys6]-Urotensin II (4-11) (cyclic 1-6, disulfide)
EINECS	Contact for details

Quality Control

Our Urantide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and MS for identity confirmation, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, peptide content, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.