Description

Cyclopropanecarboxylic Acid, 1-[(Trifluoroacetyl)Amino]- (9Ci) is a high-purity, specialized organic building block featuring a cyclopropane ring and a trifluoroacetyl-protected amino group. This compound matters as a critical intermediate in advanced pharmaceutical synthesis and agrochemical research, enabling the construction of complex molecules with unique steric and electronic properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) and metabolic diseases.
• Agrochemical Research: Used in the synthesis of advanced herbicides, fungicides, and insecticides, where the cyclopropane moiety can enhance biological activity and stability.
• Peptide Mimetics & PROTACs: Serves as a constrained, non-natural amino acid analog in the design of peptide mimetics and proteolysis-targeting chimeras (PROTACs).
• Ligand & Catalyst Development: Employed in organometallic chemistry for creating novel chiral ligands and catalysts used in asymmetric synthesis.
• Fluorine Chemistry Building Block: The trifluoroacetyl group provides a versatile handle for further fluorination or introduction of fluorinated motifs into target molecules.
• Material Science Precursor: Potential precursor for specialty polymers and advanced organic materials requiring rigid, three-dimensional structural components.

Basic Information

Product Name	Cyclopropanecarboxylic Acid, 1-[(Trifluoroacetyl)Amino]- (9Ci)
CAS No.	669066-98-2
Molecular Formula	C6H6F3NO3
Molecular Weight	197.11 g/mol
Synonyms	1-[(Trifluoroacetyl)amino]cyclopropanecarboxylic acid; 1-Amino-1-cyclopropanecarboxylic acid, N-trifluoroacetyl-; N-Trifluoroacetyl-1-aminocyclopropane-1-carboxylic acid; 1-(Trifluoroacetamido)cyclopropane-1-carboxylic acid; ATACC; TFA-ACPC; Cyclopropane-1-carboxylic acid, 1-amino-, N-trifluoroacetyl derivative
EINECS	Contact for details

Quality Control

Our Cyclopropanecarboxylic Acid, 1-[(Trifluoroacetyl)Amino]- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific research or production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.