Description

3-Fluoro-4-Iodopyridine-2-Carbonitrile is a high-value, multi-functional halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring fluorine, iodine, and nitrile functional groups on a pyridine core, makes it an exceptionally versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors, antiviral agents, and CNS-targeting drugs.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging its halogenated pyridine scaffold.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized heterocyclic compounds for organic electronic materials and liquid crystals.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to introduce complex aryl/alkynyl groups.
• Fluorine Chemistry: The presence of a fluorine atom allows for the study of fluorine-specific interactions in drug design and material properties.

Basic Information

Product Name	3-Fluoro-4-Iodopyridine-2-Carbonitrile
CAS No.	669066-35-7
Molecular Formula	C6H2FIN2
Molecular Weight	247.99 g/mol
Synonyms	4-Iodo-3-fluoropyridine-2-carbonitrile; 2-Cyano-3-fluoro-4-iodopyridine; 3-Fluoro-4-iodo-2-pyridinecarbonitrile; 3-Fluoro-4-iodopyridine-2-carbonitrile; 3-Fluoro-4-iodo-2-cyanopyridine; 2-Pyridinecarbonitrile, 3-fluoro-4-iodo-; 669066-35-7
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-Iodopyridine-2-Carbonitrile is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support cGMP compliance for advanced intermediates and can provide material for regulatory filings upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Maximum Impurity (HPLC)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.