Description

2-(5-Bromo-2-Fluorophenyl)-2-Hydroxyacetic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its specific halogenated aromatic structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), where its unique bromo-fluoro substitution pattern enables precise molecular modifications. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new therapeutic agents and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, leveraging its halogenated phenyl group for bioactivity.
• Chemical Research & Development: Serves as a versatile synthon for organic chemists exploring new reaction pathways and creating complex molecular architectures.
• Ligand and Catalyst Preparation: Employed in the preparation of specialized ligands for metal-catalyzed cross-coupling reactions.
• Material Science Precursor: Potential use in the synthesis of monomers for specialty polymers with unique optical or electronic properties.

Basic Information

Product Name	2-(5-Bromo-2-Fluorophenyl)-2-Hydroxyacetic Acid
CAS No.	668969-65-1
Molecular Formula	C8H6BrFO3
Molecular Weight	249.04 g/mol
Synonyms	5-Bromo-2-fluoromandelic acid; (5-Bromo-2-fluorophenyl)(hydroxy)acetic acid; α-Hydroxy-5-bromo-2-fluorophenylacetic acid; 2-Hydroxy-2-(5-bromo-2-fluorophenyl)acetic acid; 5-Bromo-2-fluoro-α-hydroxybenzeneacetic acid; 2-Fluoro-5-bromomandelic acid; Mandelic acid, 5-bromo-2-fluoro-
EINECS	Contact for details

Quality Control

Our production of 2-(5-Bromo-2-Fluorophenyl)-2-Hydroxyacetic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. The material is manufactured under GMP-like conditions suitable for pharmaceutical R&D. Every lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, available upon request. Our quality system is designed to meet the rigorous standards of global pharmaceutical and fine chemical supply chains.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.