Description

n-Desmethyl Dovitinib is a key pharmaceutical intermediate and metabolite of the multi-targeted receptor tyrosine kinase inhibitor Dovitinib. This compound is of significant value in drug development and pharmacokinetic studies, providing critical insights into metabolic pathways and drug efficacy. It is primarily utilized by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in oncology research and the development of kinase inhibitor therapies.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis and research of advanced kinase inhibitors.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical method development and validation for clinical and preclinical studies.
• Pharmacokinetic & Metabolism Research: Essential for studying the absorption, distribution, metabolism, and excretion (ADME) profiles of Dovitinib.
• Biochemical Research: Employed in enzymatic assays and target engagement studies to understand the mechanism of action of related therapeutics.
• Quality Control & Impurity Profiling: Acts as a known impurity or degradation product reference in the quality assurance of Dovitinib active pharmaceutical ingredient (API) and finished dosage forms.

Basic Information

Product Name	n-Desmethyl Dovitinib
CAS No.	668432-44-8
Molecular Formula	C₂₁H₂₁FN₆O₃
Molecular Weight	424.43 g/mol
Synonyms	N-Desmethyl Dovitinib; Dovitinib N-Desmethyl Metabolite; TKI258 N-Desmethyl; 5-[[5-Fluoro-2-[[(1R,2S)-2-hydroxy-1-methylpropyl]amino]-4-pyrimidinyl]amino]-2-methylbenzenesulfonamide; 4-Pyrimidinamine, 5-fluoro-N2-[(1R,2S)-2-hydroxy-1-methylpropyl]-N4-(2-methyl-5-sulfamoylphenyl)-; UNII-4F8VJ84V6F
EINECS	Contact for details

Quality Control

Our n-Desmethyl Dovitinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.