Description

3-Chloro-5-(4-Methylphenyl)Isothiazole-4-Carbonitrile is a high-value, multi-functional heterocyclic building block and advanced intermediate. Its core value lies in its unique molecular architecture, which combines an isothiazole ring with chloro, cyano, and tolyl substituents, making it a versatile synthon for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors, where it serves as a critical precursor in the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of next-generation pesticides, herbicides, and fungicides, leveraging its heterocyclic core for bioactivity.
• Material Science Research: Serves as a precursor for the development of specialty polymers, liquid crystals, and organic electronic materials due to its conjugated system and functional groups.
• Chemical Biology & Proteomics: Employed as a reactive handle or scaffold in the design of molecular probes, enzyme inhibitors, and bioconjugation reagents.
• Dye & Pigment Intermediate: Acts as a starting material for synthesizing specialized heterocyclic dyes and organic pigments with specific coloristic properties.

Basic Information

Product Name	3-Chloro-5-(4-Methylphenyl)Isothiazole-4-Carbonitrile
CAS No.	662138-23-0
Molecular Formula	C11H7ClN2S
Molecular Weight	234.70 g/mol
Synonyms	4-Cyano-3-chloro-5-(p-tolyl)isothiazole; 3-Chloro-5-(p-tolyl)isothiazole-4-carbonitrile; 5-(4-Methylphenyl)-3-chloro-4-isothiazolecarbonitrile; 3-Chloro-5-(4-methylphenyl)-4-isothiazolecarbonitrile; 662138-23-0; p-Tolyl isothiazole carbonitrile derivative
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-(4-Methylphenyl)Isothiazole-4-Carbonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.