Description

n-[1-Oxo-2-(Phenylmethyl)-2-Propenyl]Glycine Ethyl Ester is a specialized organic building block and intermediate of significant interest in advanced synthetic chemistry. Its unique structure, featuring both a glycine ethyl ester moiety and an α,β-unsaturated ketone (enone) group, makes it a versatile precursor for constructing complex molecular architectures. This compound is primarily sought after by research institutions and pharmaceutical development companies engaged in the synthesis of novel peptides, peptidomimetics, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the research and development of new active pharmaceutical ingredients (APIs), particularly for peptide-based therapeutics.
• Peptidomimetic Synthesis: Used to introduce constrained or modified amino acid residues into peptide chains, enhancing metabolic stability and biological activity.
• Chemical Biology Research: Employed as a tool compound or precursor in the study of enzyme inhibitors and receptor ligands.
• Organic Synthesis: Acts as a Michael acceptor in conjugate addition reactions or as a substrate for further functionalization of the ester and ketone groups.
• Agrochemical Research: Potential intermediate in the development of novel crop protection agents with specific biological targets.

Basic Information

Product Name	n-[1-Oxo-2-(Phenylmethyl)-2-Propenyl]Glycine Ethyl Ester
CAS No.	660848-81-7
Molecular Formula	C₁₄H₁₇NO₃
Molecular Weight	247.29 g/mol
Synonyms	Ethyl 2-[(1-oxo-2-benzylprop-2-en-1-yl)amino]acetate; 2-[(1-Oxo-2-benzyl-2-propen-1-yl)amino]acetic Acid Ethyl Ester; N-(1-Oxo-2-benzyl-2-propenyl)glycine Ethyl Ester; Glycine, N-(1-oxo-2-benzyl-2-propenyl)-, ethyl ester; Benzylideneacetyl glycine ethyl ester (related structure); Enone-modified glycine ethyl ester
EINECS	Contact for details

Quality Control

We supply n-[1-Oxo-2-(Phenylmethyl)-2-Propenyl]Glycine Ethyl Ester in high-purity grades suitable for research and development. Our products undergo rigorous quality testing to ensure batch-to-batch consistency and compliance with industry standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles—typically determined by HPLC, NMR, and mass spectrometry—is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be sensitive to moisture and prolonged exposure to air; therefore, it is recommended to handle under an inert atmosphere for long-term storage and to allow the container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.