Description

Mapatumumab CAS NO 658052-09-6 is a fully human agonistic monoclonal antibody targeting the tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1/DR4). It is a critical research-grade biologic designed to induce apoptosis in TRAIL-R1-expressing tumor cells, making it a valuable tool for oncology research and therapeutic development. This product is essential for pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on cancer biology, apoptosis signaling pathways, and the preclinical evaluation of novel cancer therapies.

Application

• Oncology Research: Investigation of apoptosis mechanisms and death receptor signaling pathways in various cancer cell lines.
• Therapeutic Antibody Development: Serves as a reference standard or lead candidate in the development of novel TRAIL-R1-targeting biologics.
• Biomarker Studies: Used in assays to characterize TRAIL-R1 expression levels in tumor tissues and cell models.
• Preclinical Evaluation: In vitro and in vivo studies to assess the efficacy and mechanism of action of pro-apoptotic agents.
• Combination Therapy Research: Exploration of synergistic effects with chemotherapy, radiotherapy, or other targeted agents.
• Immunoassay Development: Critical component in the development and validation of ELISA, flow cytometry, or immunohistochemistry protocols.

Basic Information

Product Name	Mapatumumab
CAS No.	658052-09-6
Molecular Formula	Data on request
Molecular Weight	Approx. 145 kDa
Synonyms	HGS-ETR1; TRAIL-R1 mAb; Anti-TRAIL-R1 monoclonal antibody; Anti-DR4 antibody; Apomab; TRM-1; Fully human anti-TRAIL receptor 1 antibody; Death receptor 4 agonist antibody
EINECS	Contact for details

Quality Control

Our Mapatumumab is produced and tested under stringent conditions to ensure high purity, biological activity, and consistency for research applications. Each batch is characterized for identity, purity, and potency using a suite of analytical techniques including SDS-PAGE, size-exclusion HPLC, and functional bioassays. Certificates of Analysis (COA) detailing purity, endotoxin levels, and activity are provided to guarantee it meets the rigorous standards required for preclinical and investigative use.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C to -80°C. Avoid repeated freeze-thaw cycles. Aliquot as recommended to maintain optimal activity. Refer to the specific Certificate of Analysis for detailed storage and handling instructions.

Specification

Item	Specification
Appearance	Clear to slightly opalescent, colorless to pale yellow liquid
Purity (SDS-PAGE, reducing)	> 95%
Purity (Size-exclusion HPLC)	> 98% Monomer
Protein Concentration	1.0 mg/mL (Typical, lot-specific)
Endotoxin Level	< 1.0 EU/mg
Buffer	PBS, pH 7.4 (Typical)
Biological Activity (Cell-based assay)	Confirmed

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.