Description

5-Chloro-2-Fluorophenylacetylene is a versatile and highly reactive halogenated aromatic alkyne building block. This compound is critical for advanced organic synthesis, particularly in the construction of complex molecular architectures via cross-coupling reactions. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially in kinase inhibitor and other small-molecule therapeutic programs.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides with tailored biological activity.
• Material Science: Serves as a precursor for conjugated polymers, liquid crystals, and organic electronic materials through Sonogashira and other palladium-catalyzed coupling reactions.
• Chemical Synthesis: An essential building block for creating complex organic frameworks, including natural product analogs and specialty chemicals.
• Life Science Reagents: Employed in the synthesis of molecular probes, fluorescent tags, and biochemical tools for diagnostic and research applications.

Basic Information

Product Name	5-Chloro-2-Fluorophenylacetylene
CAS No.	657425-07-5
Molecular Formula	C8H4ClF
Molecular Weight	154.57 g/mol
Synonyms	1-Chloro-4-fluoro-2-ethynylbenzene; 2-Fluoro-5-chlorophenylacetylene; (5-Chloro-2-fluorophenyl)ethyne; 2-Ethynyl-4-chlorofluorobenzene; 4-Chloro-1-fluoro-2-ethynylbenzene; 5-Chloro-2-fluoro-1-ethynylbenzene; 657425-07-5 (CAS)
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Fluorophenylacetylene is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized by modern analytical techniques including GC, HPLC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile nature, store in a cool, well-ventilated place at 2-8°C. For long-term storage, consider storage under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.