Description

2-Dicyclohexylphosphino-2',6'-Dimethoxybiphenyl is a specialized, high-value organophosphorus ligand widely recognized in the chemical industry. Its primary value lies in its exceptional performance as a supporting ligand in palladium-catalyzed cross-coupling reactions, enabling efficient and selective synthesis of complex molecules. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity catalysts for demanding synthetic applications.

Application

• Pharmaceutical Intermediate Synthesis: A key ligand for Buchwald-Hartwig amination, Suzuki-Miyaura, and other Pd-catalyzed C–N and C–C bond-forming reactions critical for API development.
• Agrochemical Research & Production: Facilitates the synthesis of complex, bioactive molecules for next-generation crop protection agents.
• Advanced Material Development: Used in the catalytic synthesis of organic electronic materials, polymers, and specialty chemicals.
• Academic & Industrial R&D: A staple reagent in catalysis research for method development and exploring new synthetic pathways.
• Process Chemistry & Scale-up: Employed in the optimization and pilot-scale production of fine chemicals due to its robustness and selectivity.

Basic Information

Product Name	2-Dicyclohexylphosphino-2',6'-Dimethoxybiphenyl
CAS No.	657408-07-6
Molecular Formula	C26H35O2P
Molecular Weight	410.53 g/mol
Synonyms	SPhos; 2-Dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl; 2-(Dicyclohexylphosphino)-2',6'-dimethoxybiphenyl; DavePhos (common trade name); SPhos Ligand; S-Phos; Biphenyl-2-yl(dicyclohexyl)phosphine derivative
EINECS	Contact for details

Quality Control

Our production of 2-Dicyclohexylphosphino-2',6'-Dimethoxybiphenyl adheres to stringent quality protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot is characterized using advanced analytical techniques, including NMR, HPLC, and elemental analysis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. The material is easily oxidized and light-sensitive; handling should be performed in a controlled, moisture-free environment to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
31P NMR	Conforms to reference spectrum
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.