Description

1H-Thieno[3,4-D]Imidazole-4-Pentanamide, n-[6-[(6-Azidohexyl)Amino]-6-Oxohexyl]Hexahydro-2-Oxo-, (3As,4S,6Ar)- is a complex, high-purity synthetic intermediate featuring a reactive azido functional group. This compound matters for its role as a critical building block in advanced pharmaceutical research and bioconjugation chemistry, enabling the development of targeted therapies and diagnostic agents. It is primarily needed by R&D scientists and process chemists in the pharmaceutical, biotechnology, and life sciences sectors for applications in drug discovery, antibody-drug conjugate (ADC) development, and proteomics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for oncology and targeted therapies.
• Bioconjugation Reagent: Used in click chemistry applications (e.g., copper-catalyzed azide-alkyne cycloaddition) for labeling proteins, antibodies, and other biomolecules.
• Antibody-Drug Conjugate (ADC) Linker Component: Serves as a functionalized spacer or linker arm in the construction of ADCs, connecting cytotoxic payloads to monoclonal antibodies.
• Proteomics Research: Employed in chemical proteomics for activity-based protein profiling (ABPP) and the study of protein function and interactions.
• Polymer & Material Science: Acts as a functional monomer or cross-linking agent for creating smart polymers, hydrogels, and surface-modified materials with specific biological activities.
• Diagnostic Agent Synthesis: Utilized in the development of contrast agents and molecular probes for imaging techniques such as PET and fluorescence microscopy.

Basic Information

Product Name	1H-Thieno[3,4-D]Imidazole-4-Pentanamide, n-[6-[(6-Azidohexyl)Amino]-6-Oxohexyl]Hexahydro-2-Oxo-, (3As,4S,6Ar)-
CAS No.	657398-08-8
Molecular Formula	C23H39N7O4S
Molecular Weight	509.67 g/mol
Synonyms	N-(6-((6-Azidohexyl)amino)-6-oxohexyl)hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide; Biotin-PEG6-azide; Biotin-PEG6-N3; Biotinylated PEG Azide; 6-Azidohexyl Biotinamidohexanoate; Azido-PEG6-Biotin; Biotin Azide; (3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanoic acid, 6-[(6-azidohexyl)amino]-6-oxohexyl ester
EINECS	Contact for details

Quality Control

Our 1H-Thieno[3,4-D]Imidazole-4-Pentanamide, n-[6-[(6-Azidohexyl)Amino]-6-Oxohexyl]Hexahydro-2-Oxo-, (3As,4S,6Ar)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure compliance with exacting R&D and cGMP-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and degradation. For long-term storage, desiccate to minimize moisture exposure. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.