Description

Acetamide, n-[1-[Tris(1-Methylethyl)Silyl]-1H-Pyrrolo[2,3-B]Pyridin-5-Yl]- is a high-value, organosilicon-protected pyrrolopyridine derivative, serving as a critical advanced pharmaceutical intermediate in modern synthetic chemistry. Its primary value lies in enabling the efficient and selective construction of complex nitrogen-containing heterocycles, which are core scaffolds in numerous active pharmaceutical ingredients. This compound is essential for R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical sectors who require reliable, high-purity building blocks for drug discovery and process development.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of kinase inhibitors and other targeted therapeutics.
• Agrochemical Synthesis: Intermediate in the development of novel herbicides and fungicides with specific mode-of-action.
• Organic Light-Emitting Diode (OLED) Materials: Precursor for electron-transport or host materials in display technologies.
• Ligand Synthesis for Catalysis: Used to prepare sophisticated nitrogen-donor ligands for transition metal catalysis.
• Academic & Industrial R&D: A versatile reagent for methodological studies in heterocyclic and organosilicon chemistry.
• Chemical Biology Probe Development: Serves as a core structure for creating molecular probes to study biological pathways.

Basic Information

Product Name	Acetamide, n-[1-[Tris(1-Methylethyl)Silyl]-1H-Pyrrolo[2,3-B]Pyridin-5-Yl]-
CAS No.	651744-46-6
Molecular Formula	C19H31N3OSi
Molecular Weight	345.56 g/mol
Synonyms	N-[1-[Tris(propan-2-yl)silyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]acetamide; 1H-Pyrrolo[2,3-b]pyridin-5-amine, N-acetyl-1-[tris(1-methylethyl)silyl]-; 5-Acetamido-1-triisopropylsilyl-7-azaindole; 1-Triisopropylsilyl-5-acetamido-7-azaindole; TIPS-5-acetamido-7-azaindole; N-(1-Triisopropylsilyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetamide; Acetamide, N-[1-[tris(1-methylethyl)silyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]-; 651744-46-6
EINECS	Contact for details

Quality Control

Our production of Acetamide, n-[1-[Tris(1-Methylethyl)Silyl]-1H-Pyrrolo[2,3-B]Pyridin-5-Yl]- adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to support your quality assurance and regulatory compliance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.