Description

Carbamic Acid, [(1R)-2-Chloro-1-(Hydroxymethyl)Ethyl]-, 1,1-Dimethylethyl Ester is a chiral, protected amino acid derivative of significant interest in advanced organic synthesis. This compound serves as a critical building block for the development of complex, biologically active molecules, offering a handle for stereoselective transformations. It is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Peptide Mimetic Synthesis: Used to incorporate modified amino acid residues into peptide chains to enhance stability, bioavailability, or biological activity.
• Agrochemical Research: Serves as a precursor in the development of novel, chiral herbicides or pesticides with improved selectivity and environmental profiles.
• Asymmetric Catalysis Substrate: Employed as a test substrate or ligand precursor in the development and optimization of new asymmetric catalytic processes.
• Chemical Biology Probe Development: Utilized to create tagged or modified molecular probes for studying enzyme mechanisms or protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing specialized fine chemicals for clients.

Basic Information

Item	Detail
Product Name	Carbamic Acid, [(1R)-2-Chloro-1-(Hydroxymethyl)Ethyl]-, 1,1-Dimethylethyl Ester
CAS No.	651035-90-4
Molecular Formula	C8H16ClNO3
Molecular Weight	209.67 g/mol
Synonyms	(R)-tert-Butyl (3-chloro-2-hydroxypropyl)carbamate; (R)-N-Boc-3-chloro-2-hydroxypropylamine; (1R)-2-Chloro-1-(hydroxymethyl)ethyl carbamic acid tert-butyl ester; (R)-3-Chloro-2-hydroxypropylcarbamic acid tert-butyl ester; tert-Butyl N-[(1R)-2-chloro-1-(hydroxymethyl)ethyl]carbamate; Boc-(R)-3-chloro-2-hydroxypropylamine; (R)-Boc-3-chloro-2-hydroxypropylamine
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols. Every batch is characterized and tested to ensure high chiral purity and chemical identity, with specifications typically meeting or exceeding 98% purity (by HPLC). We provide comprehensive Certificates of Analysis (COA) detailing assay, enantiomeric excess (ee), and impurity profiles. Our quality management system supports development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.