Description

R-(+)-N,N'-Dimethyl-7,7'-Bis(Di(3,5-Xylyl)Phosphino)-3,3',4,4'-Tetrahydro-8,8'-Bi-2H-1,4-Benzoxazine Isopropanol Adduct is a sophisticated, chiral bisphosphine ligand adduct designed for high-performance asymmetric catalysis. This compound is critical for enabling highly enantioselective transformations, offering superior control over stereochemistry in the synthesis of complex chiral molecules. It is primarily needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries for developing and scaling up advanced synthetic routes.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones in pharmaceutical intermediate synthesis.
• Asymmetric C-C Bond Formation: Catalyzes cross-coupling and addition reactions to construct chiral centers with high fidelity.
• Process Chemistry & Scale-Up: Used in the development and optimization of commercial-scale manufacturing processes for active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Employed in the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Advanced Material Research: Facilitates the synthesis of chiral polymers or molecular devices with specific optical or electronic properties.
• Academic & Industrial R&D: A valuable tool for methodological development in organic synthesis and catalysis research.

Basic Information

Product Name	R-(+)-N,N'-Dimethyl-7,7'-Bis(Di(3,5-Xylyl)Phosphino)-3,3',4,4'-Tetrahydro-8,8'-Bi-2H-1,4-Benzoxazine Isopropanol Adduct
CAS No.	649559-70-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(R)-DTBM-SEGPHOS Isopropanol Adduct; (R)-5,5'-Bis[di(3,5-xylyl)phosphino]-4,4'-bi-1,3-benzodioxole Isopropanol Adduct; (R)-DTBM-SEGPHOS·IPA; (R)-SEGPHOS Derivative with 3,5-Xylyl and Dimethylamino Groups; CAS 649559-70-6; Bisphosphine Ligand Adduct; Chiral Diphosphine-iPrOH Complex
EINECS	Contact for details

Quality Control

Every batch of our chiral ligand adduct is produced and tested under strict quality management protocols to ensure consistency and performance. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as chiral purity (enantiomeric excess), chemical purity (HPLC), and solvent content. Our quality systems support development under cGMP guidelines where required for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label. This material is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain catalytic activity and purity.

Specification

Item	Specification
Appearance	Off-white to pale yellow solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.