Description

R-(+)-N,N'-Dimethyl-7,7'-Bis(Di(3,5-Xylyl)Phosphino)-3,3',4,4'-Tetrahydro-8,8'-Bi-2H-1,4-Benzoxazine Isopropanol Adduct is a high-value, chiral bisphosphine ligand adduct designed for advanced asymmetric catalysis. This compound matters because it provides exceptional enantioselectivity and stability in demanding synthetic transformations, enabling the production of high-purity chiral intermediates. It is primarily needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries for developing and scaling up efficient synthetic routes to active pharmaceutical ingredients (APIs) and other specialty molecules.

Application

• Asymmetric Hydrogenation Catalysis: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in API synthesis.
• Pharmaceutical Intermediate Manufacturing: Critical for the production of chiral building blocks used in cardiovascular, central nervous system (CNS), and antiviral drugs.
• Agrochemical Synthesis: Used in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Enables the synthesis of specialty flavors, fragrances, and advanced materials with high optical purity.
• Academic & Industrial R&D: Serves as a sophisticated tool for methodology development in organic synthesis and catalysis research.
• Process Chemistry Optimization: Employed to improve yield, selectivity, and cost-efficiency in existing commercial-scale catalytic processes.

Basic Information

Product Name	R-(+)-N,N'-Dimethyl-7,7'-Bis(Di(3,5-Xylyl)Phosphino)-3,3',4,4'-Tetrahydro-8,8'-Bi-2H-1,4-Benzoxazine Isopropanol Adduct
CAS No.	649559-69-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(R)-DTBM-SEGPHOS; (R)-5,5'-Bis[di(3,5-xylyl)phosphino]-4,4'-bi-1,3-benzodioxole; (R)-DTBM-SEGPHOS Isopropanol Adduct; (R)-3,3',4,4'-Tetrahydro-8,8'-bi-2H-1,4-benzoxazine-7,7'-diylbis[di(3,5-dimethylphenyl)phosphine] Isopropanol Solvate; (R)-DTBM-SEGPHOS IPA Adduct; (R)-DTBM-SEGPHOS·IPA; (R)-DTBM-SEGPHOS i-PrOH Adduct; (R)-DTBM-SEGPHOS Isopropanolate
EINECS	Contact for details

Quality Control

Our R-(+)-N,N'-Dimethyl-7,7'-Bis(Di(3,5-Xylyl)Phosphino)-3,3',4,4'-Tetrahydro-8,8'-Bi-2H-1,4-Benzoxazine Isopropanol Adduct is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for sensitive catalytic applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry place. This material is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain catalytic activity and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (ee)	≥ 99.0%
Isopropanol Content	As per COA
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.