Description

(R)-1-{(S)-2-[Di(2-Furyl)Phosphino]Ferrocenyl}Ethyldi(3,5-Xylyl)Phosphine is a highly specialized, chiral ferrocenyl phosphine ligand, a cornerstone in advanced asymmetric catalysis. Its value lies in its ability to induce exceptional enantioselectivity and high catalytic activity in transition metal-catalyzed reactions, which is critical for producing single-enantiomer compounds. This ligand is essential for research and production in the pharmaceutical, agrochemical, and fine chemical industries, where precise stereochemical control is paramount for developing new active ingredients and high-value intermediates.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective hydrogenation of prochiral olefins, ketones, and imines, a key step in synthesizing chiral pharmaceutical building blocks and natural products.
• Asymmetric C-C Bond Formation: Critical for catalyzing cross-coupling reactions, allylic substitutions, and other C-C bond-forming processes with high stereoselectivity.
• Pharmaceutical Intermediate Synthesis: Enables the efficient, scalable production of single-enantiomer active pharmaceutical ingredients (APIs) for drugs targeting CNS disorders, cardiovascular diseases, and infectious diseases.
• Agrochemical Synthesis: Used in the development of enantiomerically pure herbicides, fungicides, and pesticides, where the biological activity is often specific to one stereoisomer.
• Fine Chemical and Fragrance Production: Facilitates the synthesis of complex, chiral molecules used in flavors, fragrances, and advanced materials.
• Academic and Process R&D: A vital tool for chemists in university and industrial R&D labs exploring new catalytic methodologies and optimizing synthetic routes.

Basic Information

Product Name	(R)-1-{(S)-2-[Di(2-Furyl)Phosphino]Ferrocenyl}Ethyldi(3,5-Xylyl)Phosphine
CAS No.	649559-65-9
Molecular Formula	C41H37FeO2P2
Molecular Weight	670.51 g/mol
Synonyms	(R)-(S)-Josiphos SL-J009-1; (R)-1-[(S)-2-(Bis(2-furyl)phosphino)ferrocenyl]ethyldi(3,5-xylyl)phosphine; Josiphos SL-J009-1; (R)-1-[(S)-2-(Di-2-furylphosphino)ferrocenyl]ethyldi(3,5-dimethylphenyl)phosphine; (R)-1-[(S)-2-(Dibenzofur-2-ylphosphino)ferrocenyl]ethyldi(3,5-xylyl)phosphine (common misnomer); Chiral Ferrocenyl Josiphos Ligand; SL-J009-1 Ligand; (R,S)-Josiphos Derivative
EINECS	Contact for details

Quality Control

Every batch of our chiral phosphine ligands is produced and controlled under strict inert atmosphere conditions to prevent oxidation and ensure maximum efficacy. We employ advanced analytical techniques including HPLC, NMR (¹H, ³¹P), and chiral analysis to verify identity, high chemical purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee consistency and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. The product is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Allow the sealed container to reach ambient temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Orange to red-brown powder or crystals
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Solubility	Soluble in common organic solvents (DCM, THF, Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.