Description

4-Bromo-2-Fluoro-1-(Methylsulfonyl)Benzene is a high-purity, multi-functional aromatic building block of significant importance in advanced organic synthesis. Its core value lies in the strategic placement of bromo, fluoro, and methylsulfonyl substituents, which enable precise molecular modifications and serve as key handles for cross-coupling and functional group interconversion reactions. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom acts as an excellent leaving group for Suzuki, Stille, and Buchwald-Hartwig amination reactions to construct complex biaryl systems.
• Sulfone Chemistry: The methylsulfonyl group is a versatile functional moiety for further transformations, including as an activating group for nucleophilic aromatic substitution or as a potential sulfone-based linker.
• Fluorine Chemistry Building Block: Provides a stable source of a fluorinated aromatic ring for studying structure-activity relationships (SAR) in drug discovery programs.

Basic Information

Product Name	4-Bromo-2-Fluoro-1-(Methylsulfonyl)Benzene
CAS No.	648904-84-1
Molecular Formula	C7H6BrFO2S
Molecular Weight	253.09 g/mol
Synonyms	1-Bromo-4-fluoro-2-(methylsulfonyl)benzene; 2-Fluoro-4-bromophenyl methyl sulfone; 4-Bromo-2-fluorophenyl methyl sulfone; Methyl 4-bromo-2-fluorophenyl sulfone; (4-Bromo-2-fluorophenyl)(methyl)sulfone; 648904-84-1; 4-Bromo-2-fluoro-1-(methylsulfonyl)benzene
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Fluoro-1-(Methylsulfonyl)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.