Description

4-Nitro-2-(trifluoromethoxy)anisole is a specialized aromatic compound featuring a nitro group and a trifluoromethoxy substituent, making it a valuable fluorinated building block in advanced chemical synthesis. Its unique structure provides enhanced lipophilicity and metabolic stability, which is critical for developing high-performance materials and active pharmaceutical ingredients. This intermediate is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with specific electronic and steric properties.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those requiring fluorinated motifs for improved bioavailability and target binding.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, pesticides, and fungicides, where the trifluoromethoxy group can enhance biological activity and environmental persistence.
• Material Science Research: Acts as a monomer or functionalizing agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: Employed as a standard or reagent in organic synthesis laboratories for method development and exploring new reaction pathways involving nitroarenes and aryl ethers.
• Dye and Pigment Intermediate: Utilized in the synthesis of complex, color-fast dyes and pigments for specialized industrial applications.

Basic Information

Product Name	4-Nitro-2-(trifluoromethoxy)anisole
CAS No.	647855-18-3
Molecular Formula	C8H6F3NO4
Molecular Weight	237.14 g/mol
Synonyms	1-Methoxy-4-nitro-2-(trifluoromethoxy)benzene; 2-Methoxy-5-nitro-1-(trifluoromethoxy)benzene; 4-Nitro-2-(trifluoromethoxy)phenyl methyl ether; Benzene, 1-methoxy-4-nitro-2-(trifluoromethoxy)-; Anisole, 4-nitro-2-(trifluoromethoxy)-
EINECS	Contact for details

Quality Control

Our production of 4-Nitro-2-(trifluoromethoxy)anisole adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques (HPLC, GC, NMR) to verify identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment, ensuring full transparency and compliance with your research or manufacturing specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to the presence of nitro and ether functional groups, it should be stored separately from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.