Description

Rifabutin n-Oxide CAS NO 645406-37-7 is a key pharmaceutical intermediate and metabolite of the antibiotic rifabutin. This compound is of significant importance for research and development in the pharmaceutical industry, particularly in the study of drug metabolism, pharmacokinetics, and the synthesis of related active pharmaceutical ingredients (APIs). It is primarily needed by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in the development and quality control of anti-tuberculosis and anti-mycobacterial therapies.

Application

• As a critical reference standard for the analytical quantification of rifabutin and its metabolites in biological matrices.
• Used in pharmaceutical R&D for studying the metabolic pathways and pharmacokinetic profile of rifabutin.
• Serves as a key synthetic intermediate in the preparation of novel rifamycin derivatives and related antibiotic compounds.
• Essential for impurity profiling and stability studies of rifabutin drug substances and finished dosage forms.
• Utilized in clinical research to understand patient response and potential drug-drug interactions.
• Applied in quality control laboratories to develop and validate analytical methods (e.g., HPLC, LC-MS).

Basic Information

Product Name	Rifabutin n-Oxide
CAS No.	645406-37-7
Molecular Formula	C46H62N4O12
Molecular Weight	863.01 g/mol
Synonyms	Rifabutin N-Oxide; Rifabutin Metabolite; LM 565; Ansamycin N-Oxide; (9S,12E,14S,15R,16S,17R,18R,19R,20S,21S,22E,24Z)-6,16,18,20-Tetrahydroxy-5,9,17,19,21-pentamethyl-23-(2-methyl-1-oxidopyridin-1-ium-4-yl)-2,7-dioxo-8,30-dioxa-1-azapentacyclo[23.3.1.14,7.03,22.027,31]hentriaconta-3,12,14,22,24,26,31-heptaen-15-yl acetate; Rifabutin Oxide
EINECS	Contact for details

Quality Control

Our Rifabutin n-Oxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical reference standards and intermediates. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, identity, and impurity profiles as determined by advanced techniques like HPLC and NMR.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.