Description

2-Bromomethyl-4-Chloro-1-Difluoromethoxy-Benzene is a high-value halogenated aromatic building block with significant synthetic utility. This compound is primarily valued for its role as a versatile intermediate in the development of complex organic molecules, particularly in the pharmaceutical and agrochemical sectors. It is essential for researchers and manufacturers engaged in the synthesis of active pharmaceutical ingredients (APIs), advanced materials, and specialty fine chemicals. The precise functionalization offered by its bromomethyl, chloro, and difluoromethoxy groups makes it a critical reagent for introducing specific molecular motifs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly in medicinal chemistry for creating libraries of bioactive compounds.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides where the difluoromethoxy group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromomethyl group acts as a reactive handle for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to construct complex biaryl systems.
• Fluorinated Compound Development: Critical for introducing the difluoromethoxy (-OCF2H) pharmacophore, a moiety known to improve the potency, selectivity, and pharmacokinetic properties of lead compounds.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects and scale-up processes.

Basic Information

Product Name	2-Bromomethyl-4-Chloro-1-Difluoromethoxy-Benzene
CAS No.	639826-18-9
Molecular Formula	C9H8BrClF2O
Molecular Weight	277.51 g/mol
Synonyms	4-Chloro-2-(bromomethyl)-1-(difluoromethoxy)benzene; 1-Bromo-2-(4-chloro-2-(difluoromethoxy)phenyl)ethane; Benzene, 2-(bromomethyl)-4-chloro-1-(difluoromethoxy)-; 2-(Bromomethyl)-4-chloro-1-(difluoromethoxy)benzene; 4-Chloro-α-(bromomethyl)-2-(difluoromethoxy)benzyl alcohol (precursor form); (4-Chloro-2-(difluoromethoxy)phenyl)methyl bromide
EINECS	Contact for details

Quality Control

Our 2-Bromomethyl-4-Chloro-1-Difluoromethoxy-Benzene is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical specifications. Our quality commitment aligns with cGMP principles where applicable, ensuring the material is suitable for demanding research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. Due to its light-sensitive nature and reactive bromomethyl group, prolonged exposure to light or moisture should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.