Description

4-Chloro-1-(Difluoromethoxy)-2-Methyl-Benzene is a high-purity fluorinated aromatic building block of significant interest in advanced chemical synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the difluoromethoxy group imparts desirable metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate this unique halogenated ether moiety into novel molecular architectures.

Application

• Intermediate in the synthesis of novel pharmaceutical candidates, particularly in medicinal chemistry programs targeting CNS and metabolic diseases.
• Key building block for agrochemical active ingredients, such as herbicides and fungicides, where the difluoromethoxy group enhances bioactivity.
• Precursor in material science for creating specialty monomers or ligands with tailored electronic properties.
• Versatile reagent in organofluorine chemistry research and development for introducing the -OCF2H functional group.
• Used in contract manufacturing (CMO) and custom synthesis projects requiring high-purity fluorinated intermediates.
• Reference standard for analytical method development and quality control in API manufacturing processes.

Basic Information

Product Name	4-Chloro-1-(Difluoromethoxy)-2-Methyl-Benzene
CAS No.	639826-17-8
Molecular Formula	C8H7ClF2O
Molecular Weight	192.59 g/mol
Synonyms	4-Chloro-2-methyl-1-(difluoromethoxy)benzene; 1-Chloro-4-(difluoromethoxy)-3-methylbenzene; 2-Methyl-4-chloro-1-(difluoromethoxy)benzene; Benzene, 4-chloro-1-(difluoromethoxy)-2-methyl-; 3-Methyl-4-chlorophenyl difluoromethyl ether; 4-Chloro-α,α-difluoro-2-methylanisole; 4-Chloro-2-methylanisole, α,α-difluoro-
EINECS	Contact for details

Quality Control

Our 4-Chloro-1-(Difluoromethoxy)-2-Methyl-Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ISO standards for pharmaceutical and fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and fluorinating agents. The container should be kept tightly sealed to prevent moisture absorption and potential decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.