Description

D-Fructose-5-13C CAS NO 635325-97-2 is a stable isotope-labeled analog of fructose, where the carbon-13 atom is specifically incorporated at the 5th position. This precise labeling is critical for advanced metabolic research, enabling accurate tracking and quantification of fructose pathways in biological systems using techniques like NMR spectroscopy and mass spectrometry. It is an essential tool for researchers and manufacturers in pharmaceutical development, nutritional science, and biochemical diagnostics who require high-purity tracers for reliable and reproducible data.

Application

• Metabolic Flux Analysis (MFA): Used as a stable isotopic tracer to map and quantify the metabolic pathways of fructose in cell cultures, tissues, and whole organisms.
• Pharmaceutical Research & Development: Employed in drug metabolism and pharmacokinetics (DMPK) studies to investigate the absorption, distribution, metabolism, and excretion (ADME) of fructose-related compounds.
• Clinical Diagnostics & Biomarker Discovery: Serves as an internal standard in LC-MS and GC-MS assays for the precise measurement of fructose and its metabolites in biological fluids, enhancing diagnostic accuracy.
• Nutritional Science: Facilitates research into fructose metabolism, insulin resistance, and metabolic disorders such as diabetes and non-alcoholic fatty liver disease (NAFLD).
• Enzyme Mechanism Studies: Aids in elucidating the catalytic mechanisms of enzymes like ketohexokinase (KHK) involved in fructose metabolism.
• Biotechnology & Fermentation Monitoring: Applied in process analytics to monitor substrate utilization and product formation in microbial fermentation processes involving fructose.

Basic Information

Product Name	D-Fructose-5-13C
CAS No.	635325-97-2
Molecular Formula	C6H12O6 (with 13C at position 5)
Molecular Weight	181.15 g/mol (approx.)
Synonyms	Fructose-5-13C; (3S,4R,5R)-1,3,4,5,6-Pentahydroxyhexan-2-one-5-13C; Levulose-5-13C; D-(-)-Fructose-5-13C; Fruit sugar-5-13C; Arabino-2-hexulose-5-13C
EINECS	Contact for details

Quality Control

Our D-Fructose-5-13C is produced and tested to meet the stringent requirements of research and industrial applications. Each batch undergoes comprehensive analysis to ensure high isotopic and chemical purity. A detailed Certificate of Analysis (COA) is provided, which includes data for isotopic enrichment (typically >99 atom % 13C), chemical purity (by HPLC), and specific rotation. Our quality system ensures traceability and compliance with relevant standards for isotopic labeled compounds.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Enrichment (NMR/MS)	≥ 99 atom % 13C
Assay (HPLC)	≥ 98.0% (chemical purity)
Specific Rotation	Specified range provided on COA
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.