Description

Fmoc-Nh-5(Ethylene Glycol)-Acetic Acid is a specialized, heterobifunctional polyethylene glycol (PEG) derivative designed for advanced bioconjugation and peptide synthesis. This compound is engineered to introduce a hydrophilic PEG spacer arm while providing orthogonal protection with an Fmoc group, enabling precise, site-specific modifications under mild conditions. It is an essential building block for researchers and manufacturers in pharmaceutical development, proteomics, and the creation of peptide-drug conjugates (PDCs), where solubility, stability, and controlled linkage are critical.

Application

• Peptide-Drug Conjugate (PDC) Synthesis: Serves as a key linker to attach cytotoxic drugs to targeting peptides, improving pharmacokinetics and reducing off-target effects.
• PEGylation of Biomolecules: Used to introduce a discrete, short PEG chain (5 ethylene glycol units) to peptides, proteins, or small molecules to enhance solubility and stability.
• Solid-Phase Peptide Synthesis (SPPS): Acts as a protected, PEG-containing amino acid derivative for the incorporation of hydrophilic spacers directly into peptide sequences.
• Surface Functionalization: Facilitates the biofunctionalization of nanoparticles, biosensors, and microarray surfaces with biologically active ligands.
• Cross-linking and Bioconjugation: Provides a controlled-length spacer between two different functional molecules in diagnostic assay development.
• Research & Development: A vital tool in academic and industrial R&D for exploring novel therapeutic modalities and biophysical properties of PEGylated constructs.

Basic Information

Product Name	Fmoc-Nh-5(Ethylene Glycol)-Acetic Acid
CAS No.	635287-26-2
Molecular Formula	C26H31NO9
Molecular Weight	501.53 g/mol
Synonyms	Fmoc-NH-PEG5-acetic acid; Fmoc-8-amino-3,6-dioxaoctanoic acid (PEG2 variant context); N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3,6,9,12,15-pentaoxa-2-azaheptadecan-17-oic acid; Fmoc-N-amido-PEG5-acid; 17-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3,6,9,12,15-pentaoxaheptadecanoic acid; Fmoc-NH-(CH2CH2O)5-CH2COOH; Heterobifunctional PEG5 linker, Fmoc-protected
EINECS	Contact for details

Quality Control

Our Fmoc-Nh-5(Ethylene Glycol)-Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D and bioconjugation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is moisture-sensitive; keep the container tightly sealed in a desiccated environment upon opening.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.