Description

1-{[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Azepane-2-Carboxylic Acid is a specialized Fmoc-protected amino acid derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in enabling the controlled synthesis of complex peptides and peptidomimetics, where the Fmoc group provides orthogonal protection for the amine functionality. This high-purity intermediate is essential for researchers and manufacturers in pharmaceutical development, particularly in the creation of novel therapeutic agents and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid component for the Fmoc-strategy, used in the automated synthesis of peptides for research and drug discovery.
• Pharmaceutical Intermediates: Serves as a crucial precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Peptidomimetic Development: Used to incorporate the seven-membered azepane ring structure into peptide backbones, enhancing metabolic stability and bioavailability of drug candidates.
• Bioconjugation and Probe Synthesis: Facilitates the site-specific labeling and modification of peptides and proteins for diagnostic and biochemical research.
• Combinatorial Chemistry Libraries: Employed as a diverse building block to create libraries of compounds for high-throughput screening.
• Academic and Industrial R&D: A fundamental reagent for synthetic organic chemists exploring new methodologies and novel chemical entities.

Basic Information

Product Name	1-{[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Azepane-2-Carboxylic Acid
CAS No.	632350-45-9
Molecular Formula	C23H25NO4
Molecular Weight	379.45 g/mol
Synonyms	Fmoc-Aze-OH; Fmoc-Azepane-2-carboxylic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]azepane-2-carboxylic Acid; 2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]cycloheptanecarboxylic Acid; 1-Fmoc-azepane-2-carboxylic Acid; (2S)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]azepane-2-carboxylic Acid (for enantiomer); Fmoc-2-aminoazepane-1-carboxylic Acid
EINECS	Contact for details

Quality Control

Our 1-{[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Azepane-2-Carboxylic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) detailing specific results are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.