Description

3-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide is a high-purity, synthetically valuable boronic ester derivative. This compound serves as a crucial advanced pharmaceutical intermediate and building block in modern organic synthesis, particularly for cross-coupling reactions. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and material science industries for the development of novel active compounds.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key arylboronic ester precursor for constructing biaryl and heterobiaryl scaffolds in drug discovery and material synthesis.
• Pharmaceutical Intermediate: Used in the research and development of potential active pharmaceutical ingredients (APIs), especially those targeting CNS disorders and oncology.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides with improved efficacy.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as polymers and small molecules for OLEDs and OFETs.
• Chemical Biology & Proteomics: Can be utilized as a probe or linker in bioconjugation chemistry and activity-based protein profiling.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of complex, target-specific molecules on a commercial scale.

Basic Information

Product Name	3-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide
CAS No.	631911-09-6
Molecular Formula	C14H20BNO3
Molecular Weight	261.13 g/mol
Synonyms	4-Carbamoyl-2-methylphenylboronic acid pinacol ester; 2-Methyl-4-(pinacolatoboryl)benzamide; 3-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid amide; 631911-09-6; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-methylbenzamide; 3-Methyl-4-(pinacolatoboryl)benzamide; Pinacol 3-Methyl-4-carbamoylphenylboronate
EINECS	Contact for details

Quality Control

Our 3-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client requirements for research or cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.