Description

Methyl (2S,4R)-1-[(S)-2-(Boc-Amino)-3,3-Dimethylbutanoyl]-4-Hydroxypyrrolidine-2-Carboxylate is a high-purity, non-natural amino acid derivative featuring a Boc-protected amine and a methyl ester, serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a rigid, stereochemically defined scaffold essential for constructing complex molecules with high enantiomeric purity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of peptide-based therapeutics, protease inhibitors, and other bioactive compounds where precise spatial orientation is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly for targeted therapies.
• Peptidomimetic Synthesis: Used to construct constrained peptide analogs that mimic natural peptide structures with enhanced metabolic stability and bioavailability.
• Protease Inhibitor Development: Serves as a core structural element in the design of inhibitors for enzymes like HCV NS3/4A protease and others.
• Chemical Biology Research: Employed as a tool compound or building block for studying protein-protein interactions and enzyme mechanisms.
• Asymmetric Catalysis Ligand Precursor: Can be utilized in the synthesis of chiral ligands for asymmetric hydrogenation and other catalytic transformations.
• Academic & Industrial R&D: Fundamental building block for methodological studies in organic chemistry and medicinal chemistry programs.

Basic Information

Item	Details
Product Name	Methyl (2S,4R)-1-[(S)-2-(Boc-Amino)-3,3-Dimethylbutanoyl]-4-Hydroxypyrrolidine-2-Carboxylate
CAS No.	630421-45-3
Molecular Formula	C18H32N2O6
Molecular Weight	372.46 g/mol
Synonyms	(2S,4R)-1-[(2S)-2-[(tert-Butoxycarbonyl)amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-methoxy-N-methylpyrrolidine-2-carboxamide (common misnomer); Boc-(S)-Aib-(2S,4R)-Hyp-OMe; Methyl (2S,4R)-1-[(S)-2-(tert-Butoxycarbonylamino)-3,3-dimethylbutyryl]-4-hydroxypyrrolidine-2-carboxylate; (2S,4R)-Methyl 1-((S)-2-((tert-butoxycarbonyl)amino)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxylate; tert-Butyl ((S)-1-(((2S,4R)-4-hydroxy-2-(methoxycarbonyl)pyrrolidin-1-yl)oxy)-3,3-dimethyl-1-oxobutan-2-yl)carbamate; Boc-Aib-Hyp-OMe; Aib-Hyp(Boc)-OMe
EINECS	Contact for details

Quality Control

Our Methyl (2S,4R)-1-[(S)-2-(Boc-Amino)-3,3-Dimethylbutanoyl]-4-Hydroxypyrrolidine-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure compliance with exacting research and pharmaceutical intermediate standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.